We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Amount reliance from currents using solitary sodium-selective pores into the frog surface. Characteristics. 1979; 282 (5738): 519-520 PubMed Abstract | Writer Complete Text
It indicates the fresh strong conclusions put forward through this manuscript is not warranted and that i try not to accept this new manuscript within mode
The fresh new people provides clarified several of the issues I raised in the my personal past comment. Sadly, the big difficulties have not been treated by this posting. When i made in my early in the day comment, We consider they unrealistic that all men and women points is repaired only because of the several additional sentences. As an alternative there are certain practical questions toward fresh framework and, most critically, towards data.
This means the latest solid results submit from this manuscript are not rationalized and i usually do not accept this new manuscript within this function
New experts provides made clear several of the questions I elevated when you look at the my personal prior feedback. Unfortunately, all the biggest dilemmas haven’t been addressed by this improve. When i stated in my prior review, We consider they unlikely that most men and women factors are going to be repaired only because of the a few added sentences. As an alternative you may still find specific basic issues towards experimental framework and you can, most critically, towards study.
- The number one concern is that if I adopted new malfunction away from the ways in the previous adaptation it had been you can so you’re able to decode, which have almost perfect precision, one haphazard stimulus names I chosen. Pick to own samples of it reanalysis. No matter whether we imagine that real stimuli checked on a later on time or was continuously alternating anywhere between code and you will quiet, the latest decryption is near to best. This really is a sign that decoding has nothing to complete towards actual stimulus read by the Sender it is opportunistically exploiting some other possess on the studies. The newest control research this new experts did, reversing new stimulus names, usually do not target this issue because it is affected with exactly the same disease. Essentially, just what classifier try presumably having fun with it’s time that enacted because tape started.
- The cause of it is presumably that article writers put non-independent studies to have degree and assessment. Of course I understand truthfully (discover part step three), arbitrary testing 1 / 2 of information trials out of an enthusiastic EEG trace commonly separate investigation. Repeating the study five times the latest control analysis this new article writers did isnt a sufficient cure for address which matter. Randomly looking examples out of a period of time show who has sluggish transform (for instance the slow revolution craft one to allegedly dominates these types of tracks not as much as these scenarios) have a tendency to inevitably consist of solid temporary correlations. Discover TemporalCorrelations.jpg in for 2D thickness histograms and you will a relationship matrix indicating so it.
- While the changed procedures area brings increased detail today, it still is confused about exactly what analysis were used. Old-fashioned group investigation report what analysis has (typical articles from the research matrix) and you will what observations (typical rows) were used. Things is a feature however http://essaymentor.net/apa-paper-writing-service/, typically this really is the new other EEG streams otherwise fMRI voxels an such like. Observations are usually big date points. Right here I guess new article authors switched the newest intense examples to the good different area having fun with dominant part investigation. This is simply not mentioned if the dimensionality is faster making use of the eigenvalues. In either case, I assume the content trials (accumulated at 128 Hz) was upcoming used as observations and the EEG streams turned from the PCA were used since has. The stimuli labels was basically assigned once the Towards otherwise Out of for each and every attempt. A set of 50% regarding examples (and you will labels) ended up being picked randomly to have training, and the other people was utilized to have evaluation. So is this right?